Keeping this in view, why can't I save in Red Dead Redemption 2?
The only thing I can suggest is to make sure you haven't got some mission or bounty or story element active before trying to manually save. You could also try turning auto save off/on again.
Subsequently, question is, when can I manually save in rdr2? You can save your progress manually when: You aren't doing any missions. You aren't fighting with anyone. You aren't playing any mini-games or other activities that force you to complete them.
Correspondingly, does Red Dead 2 auto save?
The game auto-saves at various points during the game including when you start and finish a mission or when your character sleeps. You can also trigger an auto-save when you buy or sell an item. To manually save your progress you will need to bring up the pause menu and the select 'Story'.
Can you save game with cheats rdr2?
You can't save your game after you've activated a cheat, so save beforehand! Once you activate any cheat you will lose the ability to earn Trophies or Achievements. Enter it and then save your game immediately - you can toggle it on/off.