Considering this, why does malate aspartate shuttle produce more ATP?
Since the malate-aspartate shuttle regenerates NADH inside the mitochondrial matrix, it is capable of maximizing the number of ATPs produced in glycolysis (3/NADH), ultimately resulting in a net gain of 38 ATP molecules per molecule of glucose metabolized.
Subsequently, question is, which organs use malate aspartate shuttle? The malate-aspartate shuttle yields approximately 3 molecules of ATP per molecule of cytosolic NADH and is found in liver, heart and kidney [Voet04]. It is quantatively the most important shuttle for the reoxidation of cytosolic NADH in vertebrate tissues under aerobic conditions.
Moreover, what happens if malate aspartate shuttle stops?
Malate–aspartate shuttle deficiency
The malate–aspartate shuttle translocates electrons produced during glycolysis into mitochondria across the inner mitochondrial membrane. Shuttle defects can thus disrupt oxidative phosphorylation.
How does the glycerol phosphate shuttle work?
Discussion. The glycerol-3-phosphate shuttle is a pathway that translocates electrons produced during glycolysis across the inner membrane of the mitochondrion for oxidative phosphorylation by oxidizing cytoplasmic NADH to NAD+.
