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Is TPPA and TPHA same?

Author

Sophia Sparks

Published Mar 15, 2026

Is TPPA and TPHA same?

The TPHA and TPPA are indirect agglutination tests in which surface antigens extracted from T. pallidum cells are coated onto red cells (TPHA) or gelatin particles (TPPA) and mixed with the test serum.

Correspondingly, is the TPHA test specific for Treponema pallidum?

Nevertheless, both treponemal and nontreponemal serologic tests for syphilis are accurate for diagnosis of syphilis; TPHA test should be used for routine confirmation of a reactive VDRL test irrespective of its titer for accurate diagnosis of syphilis, especially in cases having titer ≤1:8.

Beside above, how accurate is TPPA test? The TPPA and the 2nd EIA test are done due to the high false positive rate of treponemal tests; a single treponemal test has a positive predictive value of only 10%.

In this regard, is TPHA a syphilis?

Treponema pallidum hemagglutination commonly known as TPHA is diagnostic test used to detect the dissolved amount of antibodies in the serum sample of a patient against the causative agents of syphilis. To be precise the TPHA test helps in the detection of Palladium antibodies via the hemagglutination method.

What is TPHA test for syphilis?

The Treponema pallidum haemagglutination (TPHA) test was carried out on 274 sera known to show biological false positive reactions to reagin tests for syphilis. The Treponema pallidum immunization (TPI) and fluorescent treponemal antibody absorption (FTA-ABS) tests were non-reactive on all these sera.

Is TPHA positive curable?

When diagnosed and treated in its early stages, syphilis is easy to cure. The preferred treatment at all stages is penicillin, an antibiotic medication that can kill the organism that causes syphilis. If you're allergic to penicillin, your doctor may suggest another antibiotic or recommend penicillin desensitization.

Is TPHA positive for life?

Treponemal tests such as TPHA, having lower sensitivities in primary syphilis, remain positive despite treatment and give false positive results uncommonly.

What is the normal range of TPHA?

CSF abnormalitiesSerum TPHA titre
CSF WBC count > 5/μl, n (%)6 (6)19 (39)
Median (IQR)a7 (7–7)20 (11–41)
CSF TPHA titre ≥ 1:640, n (%)7 (7)39 (80)
Median (IQR)a1:640 (1:640–1:640)1:2560 (1:1280–1:10,240)

Will TPHA become negative?

The response of the Treponema Pallidum Haemagglutination Assay (TPHA) to treatment was studied in 61 cases of early infectious syphilis. In none of the 55 cases of early syphilis in which the pre-treatment TPHA was positive did the TPHA test become consistently negative after treatment.

What is the most accurate test for syphilis?

Tests used to confirm a syphilis infection include: Enzyme immunoassay (EIA) test. This blood test checks for syphilis antibodies. A positive EIA test should be confirmed with either the VDRL or RPR tests.

What causes TPHA?

The cause of syphilis is a bacterium called Treponema pallidum. The most common route of transmission is through contact with an infected person's sore during sexual activity. The bacteria enter your body through minor cuts or abrasions in your skin or mucous membranes.

How long does it take to cure syphilis?

You may also feel generally weak and tired. Like primary syphilis, the signs and symptoms of secondary syphilis go away on their own without treatment in 2 to 6 weeks.

What does TPHA negative mean?

A negative test result means that antibodies against Treponema Pallidum are absent indicating that the patient is not having syphilis infection. A positive test result means that antibodies against Treponema Pallidum are present indicating that the patient is having syphilis infection.

Can syphilis be cured?

Can syphilis be cured? Yes, syphilis can be cured with the right antibiotics from your health care provider. However, treatment might not undo any damage that the infection has already done.

What is anti TP test?

The Advanced Quality One Step Anti-TP (Treponema Pallidum /Syphilis) Test is a rapid, serological, immunochromatographic assay for the detection of antibodies to syphilis antigen in human whole blood, serum or plasma.

Is TPPA a Treponemal?

The Treponema pallidum particle agglutination assay (also called TPPA test) is an indirect agglutination assay used for detection and titration of antibodies against the causative agent of syphilis, Treponema pallidum subspecies pallidum. It also detects other treponematoses.

Can TPPA be false positive?

False-positive or inconclusive results for this assay may be seen in patients with HIV, leprosy, toxoplasmosis, or Helicobacter pylori.

What is late syphilis?

Early latent syphilis is latent syphilis where infection occurred within the past 12 months. Late latent syphilis is latent syphilis where infection occurred more than 12 months ago. Latent syphilis can last for years.

Will I always test positive for syphilis?

The antibodies produced as a result of a syphilis infection can stay in your body even after your syphilis has been treated. This means you might always have positive results on this test.

How long can you have syphilis without knowing?

If untreated, an infected person will progress to the latent (hidden) stage of syphilis. After the secondary-stage rash goes away, the person will not have any symptoms for a time (latent period). The latent period may be as brief as 1 year or range from 5 to 20 years.

What is the gold standard test for syphilis?

The sensitivity, specificity, and predictive values of ECOTEST-RPR and DIALAB-ELISA in this study were evaluated by using Randox-TPHA as a gold standard for the diagnosis of syphilis. Thus, the sensitivity and specificity of ECOTEST-RPR for syphilis detection were 100 and 80.8%, respectively.

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